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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1389453

Association between physical activity and sedentary behavior and gestational diabetes mellitus: A Mendelian randomization analysis

Provisionally accepted
Jie Gao Jie Gao 1Jingfang Liu Jingfang Liu 2*
  • 1 The First Clinical Medical College, Lanzhou University, Lanzhou, China
  • 2 First Hospital of Lanzhou University, Lanzhou, Gansu Province, China

The final, formatted version of the article will be published soon.

    The evidence of association between physical activity (PA), sedentary behavior (SB) and gestational diabetes mellitus (GDM) remains controversial in observational studies, this study aimed to generate new hypotheses between PA, SB and GDM.Our study performed Mendelian randomization (MR) analysis to explore the effects of three types of PA (moderate physical activity (MPA), moderate to vigorous physical activity (MVPA), accelerometer-based physical activity (ABPA)), three types of SB (television watching (TV), leisure computer use (PC), driving (DR)) on GDM and the mediating effect of body mass index (BMI). The inverse variance weighted method was used for the major analysis.In univariate MR analysis, we found that genetically predicted TV and PC among SB were associated with GDM (OR =

    Keywords: gestational diabetes mellitus, mediation mendelian randomization, Multivariate Mendelian randomization, Television watching, Body Mass Index

    Received: 13 Mar 2024; Accepted: 29 Nov 2024.

    Copyright: © 2024 Gao and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jingfang Liu, First Hospital of Lanzhou University, Lanzhou, Gansu Province, China

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