Skip to main content

ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1388731
This article is part of the Research Topic Exploring the New Biomarkers and Clinical Indicators for Diabetes: Insights from Real-World Studies View all 28 articles

Uric acid to albumin ratio is a novel predictive marker for all-cause and cardiovascular death in diabetic patients: A prospective cohort study

Provisionally accepted
Shengnan Chen Shengnan Chen 1Ming Zhang Ming Zhang 1Shouye Hu Shouye Hu 1Xiaolong Shao Xiaolong Shao 1Lin Liu Lin Liu 1Zhi Yang Zhi Yang 1Kai Nan Kai Nan 2*
  • 1 Xi'an Jiaotong University, Xi'an, Shaanxi Province, China
  • 2 Department of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, China

The final, formatted version of the article will be published soon.

    Background: Diabetes is one of the leading causes of death with an increasing prevalence worldwide. Diabetes-related premature mortality is largely preventable and reversible if identified and managed early. Accordingly, we intend to investigate the predictive value of uric acid to albumin ratio (UAR) for all-cause and cardiovascular death in diabetic patients. Methods: Univariate and multivariate Cox regression analyses were performed to identify risk factors for all-cause death of diabetic patients. The receiver operating characteristic (ROC) curves and nomogram model were used to evaluate the predictive ability of variables. Kaplan-Meier survival analysis was used to display the progression risks of diabetic patients. Results: A total of 804 diabetic patients were enrolled in the study. During the 5-year follow-up, all-cause death was found in 80 participants (9.95%) and cardiovascular death was found in 24 participants (2.99%). Age, UAR, and hsCRP were independent risk factors for all-cause death in diabetic patients after adjusting for potential confounding factors. Age and UAR had good predictive value for 1-, 3-, and 5-year all-cause death in diabetic patients, and the combination of UAR and age had the highest predictive value. An easy and intuitive prognostic nomogram model with good predictive accuracy was constructed based on age and UAR. Patients in higher quantiles of age and UAR had more rapid progression to all-cause death and higher mortality risk than patients in the lower quantiles. UAR also had good predictive value for cardiovascular death in diabetic patients. Conclusions: UAR may be a simple, cost-effective, and reliable predictive marker for all-cause and cardiovascular death in U.S. diabetic patients. The clinical utility of UAR and nomogram based on age and UAR can help physicians identify individuals at higher risk and therefore promote prevention strategies.

    Keywords: diabetes, All-cause death, Cardiovascular death, uric acid to albumin ratio, Nomogram model

    Received: 20 Feb 2024; Accepted: 31 Dec 2024.

    Copyright: © 2024 Chen, Zhang, Hu, Shao, Liu, Yang and Nan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Kai Nan, Department of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.