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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Bone Research
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1385055
This article is part of the Research Topic Insights in Bone Research: 2023 View all 7 articles

Refeeding partially reverses impaired fracture callus in undernourished rats

Provisionally accepted
Ariane Zamarioli Ariane Zamarioli 1*Iara Botega Iara Botega 1Patrícia M. Guedes Patrícia M. Guedes 1João Paulo B. Ximenez João Paulo B. Ximenez 2José B. Volpon José B. Volpon 1
  • 1 Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirão Preto, Brazil
  • 2 Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

The final, formatted version of the article will be published soon.

    Given the relation between food restriction and compromised bone quality (3,(7)(8)(9)(10)(11), 26 associated with the crucial role of a healthy bone microenvironment in proper fracture 27 healing, it is not surprising that undernutrition may lead to an impaired bone repair, resulting 28 in lower-quality bone callus. Numerous studies have investigated the effects of nutrient 29 restrictions on bone health, examining the depletion of macronutrients (such as proteins or 30 phosphate) or specific micronutrients (such as calcium or vitamin D) (9,(12)(13)(14)(15)(16)(17)(18)(19)(20). However, it 31 is worth noting that undernutrition in clinical settings often involves limited food intake, 32 leading to the restriction of multiple nutrients, and it may be better represented by a general 33 food restriction model.

    Keywords: Fracture, healing, Refeeding, undernutrition, Bone callus

    Received: 11 Feb 2024; Accepted: 03 Oct 2024.

    Copyright: © 2024 Zamarioli, Botega, Guedes, Ximenez and Volpon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ariane Zamarioli, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirão Preto, Brazil

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