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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Diabetes: Molecular Mechanisms
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1382241
This article is part of the Research Topic Metaflammation in Obesity and Diabetes View all 7 articles

A Cross-sectional Study in Adiponectin, Glucose Metabolism, and Body Composition in Cystic Fibrosis

Provisionally accepted
Bibi U. Nielsen Bibi U. Nielsen 1*Christine R. Mikkelsen Christine R. Mikkelsen 1Peter S. Oturai Peter S. Oturai 2Rikke Krogh-Madsen Rikke Krogh-Madsen 3Terese L. Katzenstein Terese L. Katzenstein 1Christian Ritz Christian Ritz 4Tacjana Pressler Tacjana Pressler 1Thomas P. Almdal Thomas P. Almdal 5Inger H. Mathiesen Inger H. Mathiesen 1Daniel Faurholt-Jepsen Daniel Faurholt-Jepsen 1
  • 1 Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
  • 2 Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark
  • 3 Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark
  • 4 Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark
  • 5 Department of Endocrinology, Rigshospitalet, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark

The final, formatted version of the article will be published soon.

    Objective: We hypothesized that the insulin-sensitizing adipokine adiponectin (ADP) is upregulated in cystic fibrosis (CF) related diabetes (CFRD) and underweight adults with CF. We aimed to assess correlations between glucose metabolism, body composition and ADP in CF. Methods: We performed a cross-sectional study among adults with CF at the Copenhagen CF Center. The study included a fasting level of ADP, an oral glucose tolerance test (OGTT), and a dual energy-x-ray absorptiometry scan. Results: In total, 115 patients were included of whom 104 had an OGTT performed. Glucose intolerance was not correlated with ADP in multivariable analysis, while increased hepatic insulin resistance (i.e., HOMA-IR) was correlated with reduced ADP levels. ADP declined by 4% (eβ 0.96, 95% CI: 0.94, 0.98), 5% (eβ 0.95, 95% CI: 0.93, 0.98), 9% (eβ 0.91, 95% CI: 0.87, 0.95), and 83% (eβ 0.17, 95% CI: 0.08, 0.37) for each one unit (kg/m2) increase in body mass index, fat mass index, muscle mass index, and bone mineral content index, respectively. Conclusions: In CF, ADP was negatively correlated with hepatic insulin resistance as well as low fat, muscle, and bone mass, but not with glucose intolerance. This suggests that malnutrition leads to higher ADP levels in CF.

    Keywords: Cystic Fibrosis, Adiponectin, fat mass, muscle mass, bone mass

    Received: 05 Feb 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Nielsen, Mikkelsen, Oturai, Krogh-Madsen, Katzenstein, Ritz, Pressler, Almdal, Mathiesen and Faurholt-Jepsen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Bibi U. Nielsen, Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

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