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STUDY PROTOCOL article

Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1380444

Conception Vessels Acupuncture Research Regularity in the Treatment of Diminished Ovarian Reserve: a multi-center, large-sample prospective cohort study protocol

Provisionally accepted
Xiaoyu Zhang Xiaoyu Zhang *Hao Sun Hao Sun Na Zhang Na Zhang Zijun Mou Zijun Mou Qingchang Xia Qingchang Xia Dongqing Du Dongqing Du Yuxia Ma Yuxia Ma
  • Shandong University of Traditional Chinese Medicine, Jinan, China

The final, formatted version of the article will be published soon.

    Background: Diminished ovarian reserve (DOR) refers to a decrease in the number or quality of oocytes in the ovarian cortex, which is a degenerative disease of the reproductive system, and can further develop into premature ovarian failure. There are few studies on acupuncture and moxibustion for DOR, which are still in the exploratory stage. Methods/design: This study was a real-world case registry study. According to whether the subjects received conception vessel acupuncture or not, they were divided into the basic treatment combined with conception vessel acupuncture group and the basic treatment group. A total of 1221 patients with DOR were enrolled and treated for 12 weeks. The percentage of patients with ≥30% improvement in anti-Müllerian hormone (AMH) was evaluated at the end of week 12. Secondary outcomes included Antral follicle count (AFC), modified Kupperman scale, basal FSH level, LH level, FSH/LH ratio, positive pregnancy, clinical pregnancy, early spontaneous abortion, ongoing pregnancy, and ectopic pregnancy. Discussion: This study provides clinical evidence and theoretical support for the treatment of DOR with conception vessel acupuncture and moxibustion, so as to guide and improve the efficacy of acupuncture and moxibustion. Trial registration: Acupuncture-Moxibustion Clinical Trial Registry ChiCTR2400080471. Registered on 30 January 2024.

    Keywords: diminished ovarian reserve, Acupuncture, Multi-center, Conception Vessels, study protocol

    Received: 01 Feb 2024; Accepted: 25 Jul 2024.

    Copyright: © 2024 Zhang, Sun, Zhang, Mou, Xia, Du and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiaoyu Zhang, Shandong University of Traditional Chinese Medicine, Jinan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.