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SYSTEMATIC REVIEW article

Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1379516
This article is part of the Research Topic Clinical Implications of Obesity and Lipid-Related Parameters on Cardiometabolic Diseases - Volume II View all 12 articles

Mendelian randomization studies of lifestyle-related risk factors for stroke: a systematic review and meta-analysise

Provisionally accepted
Yi Tian Yi Tian 1Xin Tang Xin Tang 1*Yi Liu Yi Liu 2Shu Yi Liu Shu Yi Liu 3*
  • 1 School of Clinical Medicine, Chengdu University of Traditional Chinses Medicine, Chengdu, China
  • 2 MGH Institute of Health Professions, Boston, Massachusetts, United States
  • 3 Chengdu Integrated TCM and Western Medical Hospital, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Objective: Stroke risk factors often exert long-term effects, and Mendelian randomization (MR) offers significant advantages over traditional observational studies in evaluating the causal impact of these factors on stroke. This study aims to consolidate and evaluate the relationships between potential causal factors and stroke risk, drawing upon existing MR research.Methods: A comprehensive search for MR studies related to stroke was conducted up to August 2023 using databases such as PubMed, Web of Science, Embase, and Scopus. This meta-analysis examines the relationships between potential causative factors and stroke risk. Both random-effects and fixed-effects models were utilized to compile the dominance ratios of various causative elements linked to stroke. The reliability of the included studies was assessed according to the Strengthening the Reporting of Observational Studies in Epidemiology incorporating Mendelian Randomization (STROBE-MR) guidelines.The analysis identified several risk factors for stroke, including obesity, hypertension, lowdensity lipoprotein cholesterol (LDL-C), chronic kidney disease (CKD), and smoking. Protective factors included high-density lipoprotein cholesterol (HDL-C), estimated glomerular filtration rate (eGFR), and educational attainment. Subgroup analysis revealed that type 2 diabetes mellitus (T2DM), diastolic blood pressure (DBP) are risk factors for ischemic stroke (IS).This study confirms that variables such as obesity, hypertension, elevated LDL-C levels, CKD, and smoking are significantly linked to the development of stroke. Our findings provide new insights into genetic susceptibility and potential biological pathways involved in stroke development.

    Keywords: Stroke, ischemic stroke, small vessel stroke, Mendelian Randomization Analysis, genetic epidemiology

    Received: 31 Jan 2024; Accepted: 14 Oct 2024.

    Copyright: © 2024 Tian, Tang, Liu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xin Tang, School of Clinical Medicine, Chengdu University of Traditional Chinses Medicine, Chengdu, China
    Shu Yi Liu, Chengdu Integrated TCM and Western Medical Hospital, Chengdu, 610041, Sichuan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.