Skip to main content

ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Gut Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1375374
This article is part of the Research Topic Exercise, Diet, Cytokines and Obesity View all 7 articles

Identifying the most critical behavioral lifestyles associated with MAFLD: Evidence from the NHANES 2017--2020

Provisionally accepted
Sicheng Li Sicheng Li 1*Jiajin Chen Jiajin Chen 1Yuqin Zhang Yuqin Zhang 2Shourui Huang Shourui Huang 3Qing Pan Qing Pan 3Dan Tang Dan Tang 4Tianjiao Lan Tianjiao Lan 3Shichen Bu Shichen Bu 1Yan Wang Yan Wang 1
  • 1 Xiamen University, Xiamen, China
  • 2 Sun Yat-sen University, Guangzhou, Guangdong Province, China
  • 3 Sichuan University, Chengdu, Sichuan Province, China
  • 4 Xiamen Center for Disease Control and Prevention, Xiamen, Fujian Province, China

The final, formatted version of the article will be published soon.

    Per interquartile-quartile range increases in sleep duration (OR=0.883, 95% CI: 0.826--0.944), MET (0.916, 0.871--0.963), and HEI-2015 score (0.827, 0.756--0.904) were significantly associated with MAFLD. The joint exposure of sleep duration, MET, and HEI-2015 score was associated with MAFLD (0.772, 0.688--0.865), with the highest weight (importance) for MET (0.526). PAFs revealed highergreater intervention benefits for sleep and the HEI-2015 when the majority populationsof the population (>5%) were defined ashad a low MAFLD risk (weak intervention targets), whereas MET iswas the moremost efficient intervention strategy when minority populations (≤5%) were defined ashad a low MAFLD risk (strong intervention targets). Conclusion: TheThis study founddemonstrated significant associations of between MAFLD and single and joint exposures ofto sleep duration, MET, and HEI-2015 with MAFLD and identified physical activity as the most important lifestyle factor. Further population benefit analyses may provide evidence and suggestions for population-level interventions.

    Keywords: Lifestyle exposome, MAFLD, Joint association, Multiple exposure, WQS

    Received: 23 Jan 2024; Accepted: 08 Jul 2024.

    Copyright: © 2024 Li, Chen, Zhang, Huang, Pan, Tang, Lan, Bu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Sicheng Li, Xiamen University, Xiamen, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.