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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Endocrinology of Aging
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1370985
This article is part of the Research Topic Chronic Stress, Telomeres and Aging View all 5 articles

Causal roles of circulating cytokines in sarcopenia-related traits: a Mendelian randomization study

Provisionally accepted
Zhi Chen Zhi Chen 1Jun Sun Jun Sun 2Tengbin Shi Tengbin Shi 1Chenyang Song Chenyang Song 1Chengjian Wu Chengjian Wu 1Zhengru Wu Zhengru Wu 1Jiajun Lin Jiajun Lin 1*
  • 1 Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China
  • 2 Zhaotong Traditional Chinese Medicine Hospital, Zhaotong, China

The final, formatted version of the article will be published soon.

    Background: Epidemiological and experimental evidence suggests that chronic inflammation plays an important role in the onset and progression of sarcopenia.However, there is inconsistent data on the inflammatory cytokines involved in the pathogenesis of sarcopenia. Therefore, we performed a two-sample Mendelian randomization (MR) analysis to explore the causal relationship between circulating cytokines and sarcopenia-related traits.The MR analysis utilized genetic data from genome-wide association study that included genetic variations in 41 circulating cytokines and genetic variant data for appendicular lean mass (ALM), hand grip strength, and usual walking pace. Causal associations were primarily explored using the inverse variance-weighted (IVW) method, supplemented by MR-Egger, simple mode, weighted median, and weighted mode analyses. Additionally, sensitivity analyses were also performed to ensure the reliability and stability of the results.Three cytokines [hepatocyte growth factor (HGF), interferon gamma-induced protein 10 (IP-10), and macrophage colony-stimulating factor (M-CSF)] were positively associated with ALM (β: 0.0221, 95% confidence interval (CI): 0.0071, 0.0372, P= 0.0039 for HGF; β: 0.0096, 95%CI: 4e-04, 0.0189, P= 0.0419 for IP-10; and β: 0.0100, 95%CI: 0.0035, 0.0165, P= 0.0025 for M-CSF). Conversely, higher levels of interleukin-7 (IL-7), monocyte chemotactic protein 3 (MCP-3), and regulated on activation, normal T cell expressed and secreted (RANTES) were associated with decreased hand grip strength (β: -0.

    Keywords: Inflammation, Cytokines, Sarcopenia, Causal analysis, Mendelian randomization

    Received: 15 Jan 2024; Accepted: 28 Aug 2024.

    Copyright: © 2024 Chen, Sun, Shi, Song, Wu, Wu and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jiajun Lin, Fujian Medical University Union Hospital, Fuzhou, 350001, Fujian Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.