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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 |
doi: 10.3389/fendo.2024.1368225
This article is part of the Research Topic Exploring the New Biomarkers and Clinical Indicators for Diabetes: Insights from Real-World Studies View all 17 articles
Study on risk factors of impaired fasting glucose and development of a prediction model based on Extreme Gradient Boosting (XGBoost) algorithm
Provisionally accepted- 1 The First Affiliated Hospital of Soochow University, Suzhou, China
- 2 Department of Geriatrics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China, 江苏省苏州市, China
- 3 The Affiliated Suzhou Hospital of Nanjing University Medical School, Suzhou, Jiangsu, China, 江苏省苏州市, China
- 4 Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China, 江苏省苏州市, China
The aim of this study was to develop and validate a machine learning-based model to predict the development of impaired fasting glucose (IFG) in middle-aged and older elderly people over a 5-year period using data from a cohort study.This study was a retrospective cohort study. The study population was 1855 participants who underwent consecutive physical examinations at the First Affiliated Hospital of Soochow University between 2018 and 2022.The dataset included medical history, physical examination, and biochemical index test results. The cohort was randomly divided into a training dataset and a validation dataset in a ratio of 8:2. The machine learning algorithms used in this study include Extreme Gradient Boosting (XGBoost), Support Vector Machines (SVM), Naive Bayes, Decision Trees (DT), and traditional Logistic Regression (LR). Feature selection, parameter optimization, and model construction were performed in the training set, while the validation set was used to evaluate the predictive performance of the models. The performance of these models is evaluated by an area under the receiver operating characteristic (ROC) curves (AUC), calibration curves and decision curve analysis (DCA). To interpret the best-performing model, the Shapley Additive exPlanation (SHAP) Plots was used in this study.The training/validation dataset consists of 1,855 individuals from the First Affiliated Hospital of Soochow University, yielded significant variables following selection by the Boruta algorithm and logistic multivariate regression analysis. These significant variables included systolic blood pressure (SBP), fatty liver, waist circumference (WC) and serum creatinine (Scr). The XGBoost model outperformed the other models, demonstrating an AUC of 0.7391 in the validation set.Conclusions: The XGBoost model was composed of SBP, fatty liver, WC and Scr may assist doctors with the early identification of IFG in middle-aged and elderly people.
Keywords: Impaired fasting glucose, Prediction model, artificial intelligence, cohort study, Middle-aged and elderly people
Received: 10 Jan 2024; Accepted: 04 Sep 2024.
Copyright: © 2024 崔, Pu, Li, Zheng, Lin, Liu, Xue, Zhu and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jianhong Pu, Department of Geriatrics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China, 江苏省苏州市, China
Wei Li, The Affiliated Suzhou Hospital of Nanjing University Medical School, Suzhou, Jiangsu, China, 江苏省苏州市, China
Yun Zheng, Department of Geriatrics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China, 江苏省苏州市, China
Lu Liu, Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China, 江苏省苏州市, China
Peng Xue, The Affiliated Suzhou Hospital of Nanjing University Medical School, Suzhou, Jiangsu, China, 江苏省苏州市, China
Jinzhou Zhu, Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China, 江苏省苏州市, China
Mingqing He, Department of Geriatrics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China, 江苏省苏州市, China
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