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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Pituitary Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1362950

Incidence of Bronchiectasis in Patients with Acromegaly: A Cohort Study

Provisionally accepted
Hyun-Il Gil Hyun-Il Gil 1Kyungdo Han Kyungdo Han 2Sangmo Hong Sangmo Hong 3Cheol-Young Park Cheol-Young Park 1*
  • 1 Kangbuk Samsung Hospital, Seoul, Republic of Korea
  • 2 Soongsil University, Seoul, Republic of Korea
  • 3 Hanyang University Guri Hospital, Guri-si, Gyeonggi, Republic of Korea

The final, formatted version of the article will be published soon.

    Objective: Associations between acromegaly and several respiratory diseases, such as obstructive lung disease or sleep apnea, have been suggested, but the relationship between bronchiectasis and acromegaly is unclear. We investigated whether acromegaly is related to the development of bronchiectasis.Using the Korean National Health Insurance System database between 2006 and 2016, we studied the relationship between acromegaly and bronchiectasis in patients with acromegaly (n=2593) and controls (1:5 age-and sex-matched subjects without acromegaly, n=12965) with a mean follow-up period of 8.9 years. Cox proportional hazards regression analysis was used to assess the risk of bronchiectasis in patients with acromegaly compared with controls after adjusting for age, sex, household income, place, type 2 diabetes, hypertension, and dyslipidemia.The mean age of the participants was 47.65 years, and male subjects comprised 45.62% of the cohort. The incidence rate of bronchiectasis in patients with acromegaly was 3.64 per 1,000 person-years and was significantly higher than that in controls (2.47 per 1,000 personyears) (log-rank test p = 0.002). In multivariable Cox proportional hazards regression modeling, the risk of bronchiectasis was significantly higher in patients with acromegaly than that in controls (HR: 1.49; 95% CI: 1.15-1.94, p = 0.0025) after adjusting for age, sex, household income, place, type 2 diabetes, hypertension, and dyslipidemia.Our results suggest that acromegaly may be associated with bronchiectasis.

    Keywords: non-Cystic Fibrosis Bronchiectasis, Acromegaly, Small airway disease, Growth Hormone, cohort study

    Received: 29 Dec 2023; Accepted: 01 Aug 2024.

    Copyright: © 2024 Gil, Han, Hong and Park. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Cheol-Young Park, Kangbuk Samsung Hospital, Seoul, Republic of Korea

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.