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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Endocrinology of Aging
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1362194

The association between the weight-adjusted waist index and frailty in US older adults: A Cross-Sectional Study of NHANES 2007-2018

Provisionally accepted
Huo Xingwei Huo Xingwei 1Shanshan Jia Shanshan Jia 1Lirong Sun Lirong Sun 1,2Yuanyuan Yao Yuanyuan Yao 1Chen Xiaoping Chen Xiaoping 3*
  • 1 West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • 2 Affiliated Hospital, Xizang Minzu University, Xianyang, Shaanxi Province, China
  • 3 West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China

The final, formatted version of the article will be published soon.

    Objective: This study aimed to evaluate the relationship between the weight-adjusted waist circumference index (WWI) and the frailty in American adults aged over 60 years. Methods: We utilized data from the National Health and Nutrition Examination Surveys (NHANES) spanning from 2007 to 2018. WWI was calculated using the square root of waist circumference (cm) divided by body weight (kg). The frailty index ≥ 0.25 was employed to assess frailty. Weighted multivariate logistic regression was conducted to explore the association between WWI and frailty. Generalized Additive Modeling (GAM) was used to explore potential non-linear relationships. Receiver operating characteristic curve (ROC) analysis was used to assess the predictive ability of WWI for frailty.The study encompassed 7765 8550 participants. Higher WWI was significantly associated with lower odds of frailty. In the fully adjusted model, each unit increase of WWI was associated with an 82% increased odds of frailty (OR: 1.82, 95% CI: 1.61 -2.06; P < 0.001). In the fully adjusted model, each unit increase of WWI was associated with 64% increased odds of frailty (OR: 1.64, 95% CI: 1.48 -1.82; P < 0.001). GAM found significant nonlinear relationships and threshold effects.The study presented a robust correlation between elevated WWI and increased odds of frailty among American older adults. However, these findings require further validation in large-scale, prospective studies.

    Keywords: weight-adjusted-waist index, Frailty, Obesity, NHANES, Cross-sectional study. 1. Introduction

    Received: 27 Dec 2023; Accepted: 31 Jul 2024.

    Copyright: © 2024 Xingwei, Jia, Sun, Yao and Xiaoping. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chen Xiaoping, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China

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