Skip to main content

ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Thyroid Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1361736
This article is part of the Research Topic Advances in Thyroid Surgery and Ablation Therapy - Treatment Considerations in the Era of Quality of Life View all 11 articles

The parathyroid glands identification of carbon nanoparticles via preoperative injection in reoperation of recurrent benign multinodular goiter

Provisionally accepted
Yonghui Wang Yonghui Wang 1Quancai Li Quancai Li 2*Mingxiu Fan Mingxiu Fan 2*Kunxiu Ming Kunxiu Ming 2*
  • 1 department of Thyroid & Breast Surgery, Weifang People's Hospital, Weifang, China
  • 2 Weifang People's Hospital, Weifang, Shandong Province, China

The final, formatted version of the article will be published soon.

    Benign multinodular goiter (BMNG) can grow very large and cause compression symptoms, making the operation procedure difficult. However, the recurrence rate of BMNG ranges from 3% to 43%. Reoperative thyroid surgery for BMNG is uncommon and can result in a high rate of complications, including hypoparathyroidism and recurrent laryngeal nerve palsy. Carbon nanoparticles (CNs) have been widely used as a protective agent for the parathyroid gland and as a tracer agent in central lymph node dissection. However, the protection effect of CNs in redoing BMNG has not been well illustrated. This study investigates whether CNs could protect parathyroid glands (PGs) during reoperation for patients with BMNG.BMNG patients who previously underwent thyroidectomy and received reoperation between January 2019 and January 2022 were retrospectively recruited. The Dunhill approach was employed for all patients. The patients were divided into two groups: the CNs group, who received injection CNs injection 1 hour before the operation (n = 24), and the control group, who underwent thyroid surgery without CNs injection (control group, n = 25). The numbers of PGs preserved in situ, autotransplantation, the accidental removal of the PGs, and the parathyroid hormone level were recorded and analyzed.The results revealed that more PGs were preserved in situ in the CNs group compared to the control group (3.25±0.15 vs 2.60±0.16, P=.007). Moreover, fewer PGs were subjected to autotransplantation and were accidentally discovered in the specimen in the CNs group compared to the control group. Patients who had CNs injection exhibited a lower rate of transient (5/24 vs. 13/25, P=.024) and permanent hypoparathyroidism (2/24 vs. 9/25, P=.020) compared to the control group.

    Keywords: Reoperation, thyroid, Benign multinodular goiter, Carbon nanoparticles, Hypoparathyroidism

    Received: 26 Dec 2023; Accepted: 12 Nov 2024.

    Copyright: © 2024 Wang, Li, Fan and Ming. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Quancai Li, Weifang People's Hospital, Weifang, 261000, Shandong Province, China
    Mingxiu Fan, Weifang People's Hospital, Weifang, 261000, Shandong Province, China
    Kunxiu Ming, Weifang People's Hospital, Weifang, 261000, Shandong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.