AUTHOR=Bao Zhengqing , Li Guizhong , He Feng , Xu Xiao , Liu Zhenhua , Wang Jianwei 

TITLE=The prognostic value of preoperative plasma fibrinogen in Asian patients with urothelial cancer: a systematic review and meta-analysis

JOURNAL=Frontiers in Endocrinology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1360595

DOI=10.3389/fendo.2024.1360595

ISSN=1664-2392

ABSTRACT=<sec><title>Objective</title><p>We conducted this meta-analysis to comprehensively explore the prognostic value of the preoperative plasma fibrinogen in Asian patients diagnosed with urothelial cancer (UC).</p></sec><sec><title>Methods</title><p>After a systematic search of Web of Science, PubMed, and Embase before May 2024, we included 10 studies in our meta-analysis. The hazard ratios (HRs) with 95% confidence interval (CI) for overall survival (OS), cancer-specific survival (CSS), recurrence-free survival (RFS), and progression free survival (PFS) were estimated using fixed effect model.</p></sec><sec><title>Results</title><p>This meta-analysis included a total of 2875 patients. UC patients with an elevated preoperative plasma fibrinogen had worse OS (pooled HR: 2.13, 95% CI: 1.81-2.51; P&lt;0.001), CSS (pooled HR: 2.22, 95% CI: 1.83-2.70; P&lt;0.001), RFS (pooled HR: 1.90, 95% CI: 1.59-2.27; P&lt;0.001), and PFS (pooled HR: 2.12, 95% CI: 1.36-3.29, P=0.001). No significant heterogeneity or publication bias was found. Additionally, statistically significant pooled HRs were also calculated in subgroup analysis when stratified by cancer type, country, and cut-off value.</p></sec><sec><title>Conclusions</title><p>The presence of elevated preoperative plasma fibrinogen levels is significantly correlated with unfavorable tumor outcomes in UCs.</p></sec>