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REVIEW article

Front. Endocrinol.
Sec. Cancer Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1355387

Systematic review on the role of the gut microbiota in tumors and their treatment

Provisionally accepted
Ying Shi Ying Shi 1Xiao Li Xiao Li 2*Jin Zhang Jin Zhang 3*
  • 1 University College London, London, United Kingdom
  • 2 Department of Obstetrics and Gynecology, Sheng Jing Hospital Affiliated, China Medical University, Shenyang, Liaoning Province, China
  • 3 Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan

The final, formatted version of the article will be published soon.

    Tumors present a formidable health risk with limited curability and high mortality; existing treatments face challenges in addressing the unique tumor microenvironment (hypoxia, low pH, and high permeability), necessitating the development of new therapeutic approaches. Under certain circumstances, certain bacteria, especially anaerobes or parthenogenetic anaerobes, accumulate and proliferate in the tumor environment. This phenomenon activates a series of responses in the body that ultimately produce anti-tumor effects. These bacteria can target and colonize the tumor microenvironment, promoting responses aimed at targeting and fighting tumor cells.Understanding and exploiting such interactions holds promise for innovative therapeutic strategies, potentially augmenting existing treatments and contributing to the development of more effective and targeted approaches to fighting tumors. This paper reviews the tumor-promoting mechanisms and anti-tumor effects of the digestive tract microbiome and describes bacterial therapeutic strategies for tumors, including natural and engineered anti-tumor strategies.

    Keywords: tumor, Gut Microbiota, tumorigenic effect, anti-oncogenic effect, therapy

    Received: 23 Dec 2023; Accepted: 23 Jul 2024.

    Copyright: © 2024 Shi, Li and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiao Li, Department of Obstetrics and Gynecology, Sheng Jing Hospital Affiliated, China Medical University, Shenyang, 110004, Liaoning Province, China
    Jin Zhang, Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, 404332, Taiwan

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.