AUTHOR=Magalhaes Isabelle P. A. , Boger Bibiana D. , Gomes Nathalia L. , Martins Guilherme L. P. , Bomfim Leomarques A. , Fagundes Gustavo F. C. , Rocha Roberta S. , Coelho Fernando M. A. , Chambo Jose L. , Latronico Ana Claudia , Fragoso Maria Candida B. V. , Hoff Ana O. , Mendonca Berenice B. , Menezes Marcos R. , Almeida Madson Q. TITLE=Intraoperative radiofrequency ablation for unresectable abdominal paraganglioma: a case report JOURNAL=Frontiers in Endocrinology VOLUME=15 YEAR=2024 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1346052 DOI=10.3389/fendo.2024.1346052 ISSN=1664-2392 ABSTRACT=
For pheochromocytoma and paraganglioma (PPGL), the efficacy of percutaneous ablative therapies in achieving control of metastatic tumors measuring <3 cm had been demonstrated in only few reports, and intraoperative radiofrequency ablation (RFA) of locally invasive primary PPGLs has not been reported. We presented the case of a 31-year-old man who had a 9-cm functioning unresectable PPGL. He was treated with 13 cycles of cytotoxic chemotherapy without objective tumor response, according to the Response Evaluation Criteria in Solid Tumors (RECIST). Subsequently, magnetic resonance imaging revealed a 9.0 × 8.6 × 6.0-cm retroperitoneal mass that extended to the inferior portion of the inferior vena cava, the inferior mesenteric artery, and the infrarenal aorta. Biochemical evaluation demonstrated high level of plasma normetanephrine (20.2 nmol/L, normal range <0.9 nmol/L). Genetic investigation showed the germline pathogenic variant c.1591delC (p. Ser198Alafs*22) in the