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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1327522
This article is part of the Research Topic Clinical Implications of Obesity and Lipid-Related Parameters on Cardiometabolic Diseases - Volume II View all 6 articles

Association Between Atherogenic Dyslipidemia and Muscle Quality Defined by Myosteatosis

Provisionally accepted
Hwi Seung Kim Hwi Seung Kim 1Yun Kyung Cho Yun Kyung Cho 2,3Myung Jin Kim Myung Jin Kim 2,3Min Jung Lee Min Jung Lee 4Eun Hee Kim Eun Hee Kim 4Woo Je Lee Woo Je Lee 2,3Hong-Kyu Kim Hong-Kyu Kim 4Chang Hee Jung Chang Hee Jung 2,3*
  • 1 Department of Internal Medicine, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong, Republic of Korea
  • 2 Department of Internal Medicine, Asan Medical Center, Seoul, Republic of Korea
  • 3 Asan Diabetes Center, Asan Medical Center, Seoul, Republic of Korea
  • 4 Department of Health Screening and Promotion Center, Asan Medical Center, Seoul, Republic of Korea

The final, formatted version of the article will be published soon.

    Background: Myosteatosis, ectopic fat accumulation in skeletal muscle, is a crucial component of sarcopenia, linked to various cardiometabolic diseases. This study aimed to analyze the association between dyslipidemia and myosteatosis using abdominal computed tomography (CT) in a large population. Methods: This study included 11,823 patients not taking lipid-lowering medications with abdominal CT taken between 2012 and 2013. Total abdominal muscle area (TAMA), measured at the L3 level, was segmented into skeletal muscle area (SMA) and intramuscular adipose tissue. SMA was further classified into normal attenuation muscle area (NAMA: good quality muscle) and low attenuation muscle area (poor quality muscle). NAMA divided by TAMA (NAMA/TAMA) represents good quality muscle. Atherosclerotic dyslipidemia was defined as high-density lipoprotein cholesterol (HDL-C) less than 40 mg/dL in men and 50 mg/dL in women, low-density lipoprotein cholesterol (LDL-C) greater than 160 mg/dL, triglycerides (TG) greater than 150 mg/dL, small dense LDL-C (sdLDL-C) greater than 50.0 mg/dL, or apolipoprotein B/A1 (apoB/A1) greater than 0.08.The adjusted odds ratios (ORs) of dyslipidemia according to the HDL-C and sdLDL definitions were greater in both sexes in the lower quartiles (Q1~3) of NAMA/TAMA compared with Q4. As per other definitions, the ORs were significantly increased in only women for LDL-C and only men for TG and ApoB/A1. In men, all lipid parameters were significantly associated with NAMA/TAMA, while TG and ApoB/A1 did not show significant association in women.Myosteatosis measured in abdominal CT was significantly associated with a higher risk of dyslipidemia. Myosteatosis may be an important risk factor for dyslipidemia and ensuing cardiometabolic diseases.

    Keywords: Dyslipidemia, skeletal muscle, Sarcopenia, Lipid, myosteatosis

    Received: 25 Oct 2023; Accepted: 25 Jul 2024.

    Copyright: © 2024 Kim, Cho, Kim, Lee, Kim, Lee, Kim and Jung. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chang Hee Jung, Department of Internal Medicine, Asan Medical Center, Seoul, 05505, Republic of Korea

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.