AUTHOR=Gao Xinyan , Li Xiao , Wang Fanfan , Cai Wen , Sun Shihu , Lu Shaoming 

TITLE=Effect of paternal age on clinical outcomes of in vitro fertilization-embryo transfer cycles

JOURNAL=Frontiers in Endocrinology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1325523

DOI=10.3389/fendo.2024.1325523

ISSN=1664-2392

ABSTRACT=<sec><title>Purpose</title><p>This study aimed to investigate the impact of paternal age &gt; 40 years on clinical pregnancy and perinatal outcomes among patients undergoing <italic>in vitro</italic> fertilization treatment.</p></sec><sec><title>Methods</title><p>We selected 75 male patients (aged &gt; 40 years) based on predefined inclusion and exclusion criteria. Propensity score matching was performed in a 1:3 ratio, resulting in a control group (aged ≤ 40 years) of 225 individuals. Various statistical tests, including the Mann-Whitney U test, Chi-square test, Fisher’s exact test, and binary logistic regression, were used to analyze the association between paternal age and clinical outcomes.</p></sec><sec><title>Results</title><p>We found no statistically significant differences in semen routine parameters, clinical pregnancy outcomes, and perinatal outcomes between paternal aged &gt; 40 and ≤ 40 years. However, in the subgroup analysis, the live birth rate significantly decreased in those aged ≥ 45 compared to those aged 41–42 and 43–44 years (31.25% vs. 69.23% and 65%, respectively; all p &lt; 0.05). Additionally, the clinical pregnancy rate was significantly lower among those aged ≥ 45 than among those aged 41–42 (43.75% vs. 74.36%; p=0.035).</p></sec><sec><title>Conclusion</title><p>Paternal age ≥ 45 years was associated with lower live birth and clinical pregnancy rates.</p></sec>