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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1325523
This article is part of the Research Topic The Future of Andrology and Infertility View all 7 articles

Effect of paternal age on clinical outcomes of in vitro fertilizationembryo transfer cycles

Provisionally accepted
Gao Xinyan Gao Xinyan 1Li Xiao Li Xiao 2Wang Fanfan Wang Fanfan 2Cai Wen Cai Wen 2Sun Shihu Sun Shihu 3Lu Shaoming Lu Shaoming 2*
  • 1 Qingdao University, Qingdao, Shandong Province, China
  • 2 Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China
  • 3 Tengzhou Maternal and Child Health Hospital, Tengzhou, China

The final, formatted version of the article will be published soon.

    This study aimed to investigate the impact of paternal age > 40 years on clinical pregnancy and perinatal outcomes among patients undergoing in vitro fertilization treatment. Methods: We selected 75 male patients (aged > 40 years) based on predefined inclusion and exclusion criteria. Propensity score matching was performed in a 1:3 ratio, resulting in a control group (aged ≤ 40 years) of 225 individuals. Various statistical tests, including the Mann-Whitney U test, Chi-square test, Fisher's exact test, and binary logistic regression, were used to analyze the association between paternal age and clinical outcomes.We found no statistically significant differences in semen routine parameters, clinical pregnancy outcomes, and perinatal outcomes between paternal aged > 40 and ≤ 40 years. However, in the subgroup analysis, the live birth rate significantly decreased in those aged ≥ 45 compared to those aged 41-42 and 43-44 years (31.25% vs. 69.23% and 65%, respectively; all p < 0.05).Additionally, the clinical pregnancy rate was significantly lower among those aged ≥ 45 than among those aged 41-42 (43.75% vs. 74.36% ; p=0.035).Paternal age ≥ 45 years was associated with lower live birth and clinical pregnancy rates.

    Keywords: Paternal Age, live birth rate, Clinical pregnancy rate, Perinatal outcomes, in vitro fertilization

    Received: 21 Oct 2023; Accepted: 12 Aug 2024.

    Copyright: © 2024 Xinyan, Xiao, Fanfan, Wen, Shihu and Shaoming. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lu Shaoming, Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, 250001, Shandong Province, China

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