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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Neuroendocrine Science
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1322114

Lipid on Stroke in Intracranial Artery Atherosclerotic Stenosis: A Mediation Role of Glucose

Provisionally accepted
Sheng Li Sheng Li 1Yiqing Wang Yiqing Wang 2Xiangyi Zhu Xiangyi Zhu 2He Zheng He Zheng 2Jianqiang Ni Jianqiang Ni 2Hao Li Hao Li 3*Yi Yang Yi Yang 2*
  • 1 Suzhou Wuzhong People’s Hospital, Suzhou, Jiangsu Province, China
  • 2 The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
  • 3 Suzhou Dushu Lake Hospital, Suzhou, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    Abstract Objective: Expanding on previous investigations, this study aims to elucidate the role of lipid metabolism disorders in the development of intracranial atherosclerotic stenosis (ICAS) and the determination of stroke risk. The primary objective is to explore the connections between lipid parameters and acute ischemic stroke (AIS), while also examining the potential mediating influence of fasting glucose levels. Methods: Retrospectively, we collected data from symptomatic ICAS patients at the First Affiliated Hospital of Soochow University, including their baseline information such as medical histories and admission blood biochemical parameters. Stenotic conditions were evaluated using magnetic resonance imaging, computed tomography angiography, or digital subtraction angiography. The associations between lipid parameters and AIS risks were investigated via multivariate logistic regression analysis. Results: A total of 1103 patients with symptomatic ICAS were recruited, among whom 441 (40.0 %) suffered new ischemic events during hospitalization. After adjusting for confounding factors, the RCS curves exhibited a dose-response relationship between the atherogenic index of plasma (AIP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and AIS. Further multivariate analysis revealed significant associations between these parameters and AIS. Furthermore, mediation analysis indicated that fasting blood glucose (FBG) acted as a mediator in the association between lipid parameters (AIP, TC, and TG) and AIS. Conclusion: Higher lipid parameters in ICAS patients, particularly AIP, TC, and TG, were associated with an increased AIS risk. Additionally, FBG may mediate stroke risk in ICAS patients, highlighting the need for further exploration of underlying mechanisms.

    Keywords: Lipid Metabolism, Intracranial Artery Atherosclerotic Stenosis, Stroke, Mediation, Glucose

    Received: 15 Oct 2023; Accepted: 29 Jul 2024.

    Copyright: © 2024 Li, Wang, Zhu, Zheng, Ni, Li and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Hao Li, Suzhou Dushu Lake Hospital, Suzhou, Jiangsu Province, China
    Yi Yang, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.