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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1108969
This article is part of the Research Topic Effects of Prenatal Exposure to Endocrine-Disrupting Chemicals View all 5 articles

A pilot study: Relationship between Bisphenol A, Bisphenol-glucuronide and total 25 hydroxy Vitamin D in maternal-child pairs in a South African population

Provisionally accepted
Verena Gounden Verena Gounden 1,2*Rajen Nithiseelan Naidoo Rajen Nithiseelan Naidoo 2Anil Chuturgoon Anil Chuturgoon 2
  • 1 National Health Laboratory Service (NHLS), Johannesburg, South Africa
  • 2 University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa

The final, formatted version of the article will be published soon.

    Exposure to Bisphenol A (BPA) during early development particularly in-utero has been linked to a wide range of pathology. Over the last two decades the importance of vitamin D in maternal and child health has been highlighted. The aim of this pilot study was to examine the relationship of BPA and its naturally occurring metabolite BPA-glucuronide (BPA-g) with 25-hydoxy vitamin D (25OHD) levels in South African mother-child pairs. Third-trimester serum maternal samples and matching cord blood samples were analyzed for BPA and BPA-g using liquid chromatography tandem mass spectrometry (LC-MS/MS) and 25OHD3 and 25OHD2 using high performance liquid chromatography.A total of 58 maternal and child pairs were analyzed. More than fifty percent of maternalchild pairs were noted to be vitamin D deficient or insufficient using the Endocrine Society Practice guidelines cut-off of 50 nmol/L. Spearman rank correlation and Kruskal Wallis analysis did not show statistically significant relationship between cord 25OHD (total) and maternal and cord BPA-g concentrations. Analysis of covariance after controlling for confounders showed a significant relationship between cord BPA-g levels and cord 25OHD levels (p=0.03) as well as between maternal BPA-g levels (p=0.04) and cord total 25OHD levels (p=0.04). The findings of the current study indicate a possible relationship with BPA/BPA-g and foetal/early infant Vitamin D levels that needs to be further investigated in this population.

    Keywords: Bisphenol-A, Vitamin D, high performance liquid chromatography, Mother-child pairs, cord blood, Abbreviations: Bisphenol-A: BPA Bisphenol glucuronide: BPA-g 25OHD:25 hydroxy vitamin D

    Received: 26 Nov 2022; Accepted: 24 Sep 2024.

    Copyright: © 2024 Gounden, Naidoo and Chuturgoon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Verena Gounden, National Health Laboratory Service (NHLS), Johannesburg, South Africa

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