AUTHOR=Kim Shin-Hee , Kim Sung Eun , Kim Seulki , Ahn Moon Bae , Cho Won Kyoung , Cho Kyoung Soon , Jung Min Ho 

TITLE=The association of serum irisin with anthropometric, metabolic, and bone parameters in obese children and adolescents

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1326851

DOI=10.3389/fendo.2023.1326851

ISSN=1664-2392

ABSTRACT=<sec><title>Background</title><p>Irisin is an adipomyokine secreted by muscle and adipose cells, and it plays a role in glucose, fat, and bone metabolism. This study aimed to determine the correlation of serum irisin levels with anthropometric, metabolic, and bone parameters in obese children and adolescents.</p></sec><sec><title>Methods</title><p>This single-center study included 103 Korean children and adolescents: 54 (52.4%) obese participants with a body mass index (BMI) ≥95th percentile and 49 (47.6%) healthy controls with BMI within the 15th to 85th percentile. Various parameters were measured, including fasting blood glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride and glucose (TyG) index, lipid profile, alkaline phosphatase (ALP), osteocalcin, and 25(OH)-Vitamin D levels. Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry (DEXA) in 33 healthy subjects.</p></sec><sec><title>Results</title><p>Serum irisin was significantly higher in the obese group than in the control group (mean 18.1 ± 3.5 vs. 16.2 ± 2.0 ng/mL; <italic>p</italic> = 0.001). Serum irisin level was positively correlated with chronological age (<italic>r</italic> = 0.28; <italic>p</italic> = 0.004), height SDS (<italic>r</italic> = 0.24; <italic>p</italic> = 0.02), BMI SDS (<italic>r</italic> = 0.37; <italic>p</italic> &lt; 0. 001), fasting glucose (<italic>r</italic> = 0.27; <italic>p</italic> = 0.007), fasting insulin (<italic>r</italic> = 0.23; <italic>p</italic> = 0.03), HOMA-IR (<italic>r</italic> = 0.21; <italic>p</italic> = 0.04), osteocalcin (<italic>r</italic> = 0.27; <italic>p</italic> = 0.006) and negatively correlated with HDL cholesterol (<italic>r</italic> = -0.29; <italic>p</italic> = 0.005). All these correlations were evident in obese subjects but not in healthy subjects. ALP and 25(OH)-Vitamin D were unrelated to irisin levels. Among 33 healthy subjects, total body-less head (TBLH) BMD Z-score was positively correlated with serum irisin (<italic>r</italic> = 0.39; <italic>p</italic> = 0.03), osteocalcin (<italic>r</italic> = 0.40; <italic>p</italic> = 0.02), fasting insulin (<italic>r</italic> = 0.39; <italic>p</italic> = 0.04), and HOMA-IR (<italic>r</italic> = 0.38; <italic>p</italic> = 0.047).</p></sec><sec><title>Conclusion</title><p>This study demonstrated an association between irisin levels and glucose, lipid, and bone parameters in children and adolescents. Our findings suggest that irisin has a potential role in metabolic disorders and bone health in obese children and adolescents.</p></sec>