AUTHOR=Chen Rumeng , Xu Shuling , Ding Yining , Li Leyang , Huang Chunxia , Bao Meihua , Li Sen , Wang Qiuhong 

TITLE=Dissecting causal associations of type 2 diabetes with 111 types of ocular conditions: a Mendelian randomization study

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1307468

DOI=10.3389/fendo.2023.1307468

ISSN=1664-2392

ABSTRACT=<sec><title>Background</title><p>Despite the well-established findings of a higher incidence of retina-related eye diseases in patients with diabetes, there is less investigation into the causal relationship between diabetes and non-retinal eye conditions, such as age-related cataracts and glaucoma.</p></sec><sec><title>Methods</title><p>We performed Mendelian randomization (MR) analysis to examine the causal relationship between type 2 diabetes mellitus (T2DM) and 111 ocular diseases. We employed a set of 184 single nucleotide polymorphisms (SNPs) that reached genome-wide significance as instrumental variables (IVs). The primary analysis utilized the inverse variance-weighted (IVW) method, with MR-Egger and weighted median (WM) methods serving as supplementary analyses.</p></sec><sec><title>Results</title><p>The results revealed suggestive positive causal relationships between T2DM and various ocular conditions, including “Senile cataract” (OR= 1.07; 95% CI: 1.03, 1.11; <italic>P</italic>=7.77×10<sup>-4</sup>), “Glaucoma” (OR= 1.08; 95% CI: 1.02, 1.13; <italic>P</italic>=4.81×10<sup>-3</sup>), and “Disorders of optic nerve and visual pathways” (OR= 1.10; 95% CI: 0.99, 1.23; <italic>P</italic>=7.01×10<sup>-2</sup>).</p></sec><sec><title>Conclusion</title><p>Our evidence supports a causal relationship between T2DM and specific ocular disorders. This provides a basis for further research on the importance of T2DM management and prevention strategies in maintaining ocular health.</p></sec>