This article is an erratum on:
The role of GABA in islet function
An Erratum on
The role of GABA in islet function
by Hagan DW, Ferreira SM, Santos GJ and Phelps EA (2022) Front. Endocrinol. 13:972115. doi: 10.3389/fendo.2022.972115
Due to a production error, there was a mistake in the penultimate sentence of the caption of Figure 1. The subscript “A” in “GABAAR” should have been “B”. The corrected caption appears below, along with Figure 1.
FIGURE 1
Figure 1 GABA in the whole islet. Application of exogenous GABA has various effects on the islet including stimulation of beta cell regeneration, inhibition of insulin secretion, and negative regulation of immune cells. Endogenous GABA levels are highly enriched in the islet, as high as in the brain, and GABA is synthesized in and secreted from the beta cells. Immunofluorescence image depicts a human islet. GABA is secreted via multiple pathways that are both regulated and unregulated by glucose and with pulsatile, tonic, or phasic dynamics. Once secreted, GABA acts via GABAAR ligand-gated chloride channels and GABAAR inhibitory G protein coupled receptors. Set by the chloride equilibrium potential, in beta cells GABAAR signaling can be excitatory in low glucose and inhibitory in high glucose, while in alpha cells GABAAR signaling is inhibitory. GABABR signaling is also inhibitory but may only be active in mouse and not human beta cells under typical physiological conditions. Created with BioRender.com.
The publisher apologizes for this mistake. The original version of this article has been updated.
Keywords: γ-Aminobutyric acid (GABA), islet, pancreas, signaling, receptor, insulin, beta cell
Citation: Frontiers Production Office (2023) Erratum: The role of GABA in islet function. Front. Endocrinol. 14:1301830. doi: 10.3389/fendo.2023.1301830
Received: 25 September 2023; Accepted: 25 September 2023;
Published: 02 October 2023.
Approved by:
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