AUTHOR=Wu Pengfei , Shan Weiwei , Xue Yu , Wang Lulu , Liu Sijia , Chen Xiaojun , Luo Xuezhen 

TITLE=Impacts of ovarian reserve on conservative treatment for endometrial cancer and atypical hyperplasia

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1286724

DOI=10.3389/fendo.2023.1286724

ISSN=1664-2392

ABSTRACT=<sec><title>Objectives</title><p>Real-world data indicated that some endometrial atypical hyperplasia (EAH) and early endometrial carcinoma (EEC) patients of fertility preservation had a normal ovarian reserve, while some had a decreased ovarian reserve (DOR). This study was designed to investigate the effect of baseline ovarian reserve on the treatment of EAH and EEC patients who ask for preservation of fertility.</p></sec><sec><title>Methods</title><p>This was a prospective cohort study conducted at a single university-affiliated fertility center. A total of 102 EAH and EEC patients who received fertility-preserving treatment between March 2019 and August 2020 were included and divided into a DOR group (n=22) and a non-DOR group (n=80).</p></sec><sec><title>Results</title><p>The 32-week CR rate of the non-DOR group was significantly higher than that of the DOR group (60.3% vs. 33.3%, <italic>P</italic> =0.028). The DOR group had a longer treatment duration to achieve CR than the non-DOR group (40.07 vs. 29.71 weeks, <italic>P</italic>=0.008, HR: 0.54, 95% CI: 0.36–0.86). Multivariate logistic regression analyses demonstrated that DOR (OR: 0.35, 95% CI: 0.13–0.99, <italic>P</italic>=0.049) and BMI ≥25 kg/m<sup>2</sup> (OR: 0.40, 95% CI: 0.17–0.92, <italic>P</italic>=0.031) were negatively associated with 32-week CR.</p></sec><sec><title>Conclusions</title><p>Decreased baseline ovarian reserve is negatively correlated with the efficacy of fertility-preserving treatment in EAH and EEC patients, as this group has a lower CR rate and a longer treatment duration to achieve CR than those without DOR.</p></sec>