AUTHOR=Yang Fang , Lu Jin-Chun , Shen Tao , Jin Yi-Han , Liang Yuan-Jiao 

TITLE=Effect of hyperlipidemia on the outcome of in vitro fertilization in non-obese patients with polycystic ovary syndrome

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1281794

DOI=10.3389/fendo.2023.1281794

ISSN=1664-2392

ABSTRACT=<sec><title>Introduction</title><p>It is little known whether hyperlipidemia alone has adverse effects on the outcome of <italic>in vitro</italic> fertilization (IVF) in patients with polycystic ovarian syndrome (PCOS).</p></sec><sec><title>Methods</title><p>The PCOS patients with body mass index (BMI) &lt; 30 kg/m<sup>2</sup> were performed IVF or intracytoplasmic sperm injection treatment, including 208 fresh cycles and 127 frozen embryo transfer (FET) cycles. All the patients were divided into hyperlipidemia and control groups, and embryo quality and pregnancy outcomes between the two groups were compared.</p></sec><sec><title>Results</title><p>In the fresh cycles, total gonadotropin dosage in the control group was significantly lower than that in the hyperlipidemia group, and serum estradiol levels on trigger day were reversed (<italic>P</italic> &lt; 0.05). The embryo fragment score was positively correlated with serum low-density lipoprotein level (<italic>r</italic> = 0.06, <italic>P</italic> &lt; 0.05) and negatively with serum high-density lipoprotein (HDL) and lipoprotein A levels (<italic>r</italic> = -0.489 and -0.085, <italic>P</italic> &lt; 0.01). Logistic regression analysis found that HDL was beneficial for clinical pregnancy (OR = 0.355, 95% <italic>CI</italic>: 0.135-0.938, <italic>P</italic> &lt; 0.05). In the FET cycles, there were no differences in pulse index, systolic/diastolic ratio and serum estradiol and progesterone levels between the two groups, but resistance index in the hyperlipidemia group was significantly higher than that in the control group (<italic>P</italic> &lt; 0.05).</p></sec><sec><title>Conclusion</title><p>Hyperlipidemia may increase the dosage of gonadotropin and have adverse effect on the embryo quality, endometrial receptivity, and clinical outcomes of lean PCOS patients. It is recommended that the non-obese patients with hyperlipidemia and PCOS perform lipid-lowering treatment before undergoing embryo transfer.</p></sec>