AUTHOR=Shen Chongrong , Chen Yanru , Wang Qiaoling , Sun Yingkai , Lin Huibin , Ni Mengshan , Chen Yufei , Zhang Ling , Jin Jiabin , Ying Xiayang , Zou Yuyao , Wang Xiaolin , Ye Yaorui , Yuan Miaomiao , Yin Nan , Cao Zhiwen , Zhang Yifei , Gu Weiqiong , Wang Weiqing , Ning Guang , Wang Jiqiu , Zhao Shaoqian , Hong Jie , Liu Ruixin TITLE=Fecal short chain fatty acids modify therapeutic effects of sleeve gastrectomy JOURNAL=Frontiers in Endocrinology VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1277035 DOI=10.3389/fendo.2023.1277035 ISSN=1664-2392 ABSTRACT=Aims

We aimed to investigate changes of fecal short chain fatty acids (SCFAs) and their association with metabolic benefits after sleeve gastrectomy (SG). Specifically, whether pre-surgery SCFAs modify surgical therapeutic effects was determined.

Methods

62 participants with measurements of fecal SCFAs and metabolic indices before and 1, 3, 6 months after SG were included. Changes of fecal SCFAs and their association with post-surgery metabolic benefits were calculated. Then, participants were stratified by medians of pre-surgery fecal SCFAs and modification effects of pre-surgery fecal SCFAs on surgical therapeutic effects were investigated, through calculating interaction of group by surgery.

Results

Fecal SCFAs were markedly changed by SG. Changes of propionate and acetate were positively correlated with serum triglycerides and total cholesterol, respectively. Notably, high pre-surgery fecal hexanoate group showed a better effect of SG treatment on lowering body weight (P=0.01), BMI (P=0.041) and serum triglycerides (P=0.031), and low pre-surgery fecal butyrate had a better effect of SG on lowering ALT (P=0.003) and AST (P=0.019).

Conclusion

Fecal SCFAs were changed and correlated with lipid profiles improvement after SG. Pre-surgery fecal hexanoate and butyrate were potential modifiers impacting metabolic benefits of SG.