AUTHOR=Wang Mei , Tong Jiao , Zhu Qing , Tang Huaiyun , Tang Lisha 

TITLE=Blood nesfatin-1 levels in patients with polycystic ovary syndrome: a systematic review and meta-analysis

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1275753

DOI=10.3389/fendo.2023.1275753

ISSN=1664-2392

ABSTRACT=<sec><title>Background</title><p>Previous studies have investigated the relationship between nesfatin-1 level and polycystic ovary syndrome (PCOS). However, these studies have produced conflicting results. Thus, in this meta-analysis, we aimed to clarify the association between blood nesfatin-1 levels and PCOS, and the ability of nesfatin-1 as a biomarker in PCOS.</p></sec><sec><title>Methods</title><p>Meta-analysis was performed using STATA 12.0 software. We computed standard mean difference (SMD) and 95% confidence interval (CI) regarding the comparison of blood nesfatin-1 in patients with PCOS and controls.</p></sec><sec><title>Results</title><p>The present meta-analysis showed no significant difference in blood nesfatin-1 level between patients with PCOS and controls with a random effects model (SMD = 0.03; 95%CI: -0.71, 0.77; I<sup>2 =</sup> 97.1%, <italic>p</italic> value for Q test &lt; 0.001). Subgroup analysis for different ethnicities reported no significant difference in blood nesfatin-1 level between patients with PCOS and controls in both Caucasian and Asian populations. Subgroup analysis for different sample types reported no significant difference in serum nesfatin-1 level between patients with PCOS and controls. Subgroup studies reported no significant difference in blood nesfatin-1 level between PCOS and controls in both obese and non-obese populations.</p></sec><sec><title>Conclusion</title><p>In conclusion, there is no significant relationship between blood nesfatin-1 levels and PCOS.</p></sec>