AUTHOR=Yang Tingting , Wang Yating , Zhang Xiaoke , Xiang Siyun , Wen Jing , Wang Wen , Guan Ke , Wang Weixiang , Yang Yang , Hao Liuwei , Chen Yongchun 

TITLE=Prevalence and influencing factors of abnormal carotid artery intima-media thickness in Henan Province in China

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1266207

DOI=10.3389/fendo.2023.1266207

ISSN=1664-2392

ABSTRACT=<sec><title>Background</title><p>Carotid intima-media thickness (CIMT) has been shown to be a valuable predictor of cardiovascular diseases (CVDs). The aim of this study was to investigate the influencing factors of CIMT among adults in Central China.</p></sec><sec><title>Methods</title><p>A total of 2,578 participants who underwent physical examination in Henan Provincial People’s Hospital between January 2018 and July 2018 were enrolled. The respondents were divided into two subgroups according to their CIMT value (CIMT ≥1.0 mm group and CIMT &lt;1.0 mm group). Variables considered were age, gender, total cholesterol, triglycerides, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) triglycerides, fasting blood glucose, and uric acid levels, as well as hypertension, diabetes, body mass index (BMI), waist-to-hip ratio, body fat percentage, and visceral fat area (VFA). Logistic regression analysis was performed to explore the potential factors influencing CIMT.</p></sec><sec><title>Results</title><p>The proportion of CIMT ≥1.0 mm among the physical examination population was 27.42% (707/2 578). The analysis of the two groups revealed significant differences in age, sex, hypertension, diabetes, total cholesterol, and HDL cholesterol. In the logistic regression analysis, age (<italic>OR</italic>=1.071, 95%<italic>CI</italic>=1.062–1.080), male sex (<italic>OR</italic>=2.012, 95%<italic>CI</italic>=1.251–2.238), hypertension (<italic>OR</italic>=1.337, 95%<italic>CI</italic>=1.031–1.735), diabetes (<italic>OR</italic>=1.535, 95%<italic>CI</italic>=1.045–2.255), HDL cholesterol (<italic>OR</italic>=0.540, 95%<italic>CI</italic>=0.366–0.796), and LDL cholesterol (<italic>OR</italic>=1.336, 95%<italic>CI</italic>=1.154–1.544) were significantly associated with abnormal CIMT.</p></sec><sec><title>Conclusion</title><p>Early screening should be carried out among men, the older adults, and those with hypertension, diabetes, and dyslipidemia.</p></sec>