AUTHOR=Pérez-Arana Gonzalo-Martín , Díaz-Gómez Alfredo , Bancalero-de los Reyes José , Gracia-Romero Manuel , Ribelles-García Antonio , Visiedo Francisco , González-Domínguez Álvaro , Almorza-Gomar David , Prada-Oliveira José-Arturo 

TITLE=The role of glucagon after bariatric/metabolic surgery: much more than an “anti-insulin” hormone

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1236103

DOI=10.3389/fendo.2023.1236103

ISSN=1664-2392

ABSTRACT=<p>The biological activity of glucagon has recently been proposed to both stimulate hepatic glucose production and also include a paradoxical insulinotropic effect, which could suggest a new role of glucagon in the pathophysiology type 2 diabetes mellitus (T2DM). An insulinotropic role of glucagon has been observed after bariatric/metabolic surgery that is mediated through the GLP-1 receptor on pancreatic beta cells. This effect appears to be modulated by other members of the proglucagon family, playing a key role in the beneficial effects and complications of bariatric/metabolic surgery. Glucagon serves a dual role after sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB). In addition to maintaining blood glucose levels, glucagon exhibits an insulinotropic effect, suggesting that glucagon has a more complex function than simply an “anti-insulin hormone”.</p>