AUTHOR=Chung Jin Ook , Park Seon-Young , Cho Dong Hyeok , Chung Dong Jin , Chung Min Young 

TITLE=Relationship between plasma leucine-rich α-2-glycoprotein 1 and urinary albumin excretion in patients with type 2 diabetes

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1232021

DOI=10.3389/fendo.2023.1232021

ISSN=1664-2392

ABSTRACT=<sec><title>Aims</title><p>To explore the relationship between plasma leucine-rich α-2-glycoprotein 1 (LRG1) level and the degree of urinary albumin excretion in patients with type 2 diabetes.</p></sec><sec><title>Methods</title><p>We evaluated 332 patients with type 2 diabetes in a cross-sectional study.</p></sec><sec><title>Result</title><p>The plasma LRG1 level differed significantly according to the quartiles of urinary albumin excretion (Q1 [&lt;7.7 mg/g], 17.1 μg/mL; Q2 [7.7–15.0 mg/g], 17.5 μg/mL; Q3 [15.1–61.4 mg/g], 18.6 μg/mL; Q4 [≥61.5 mg/g], 22.3 μg/mL; <italic>p</italic> for trend = 0.003) under adjustment with other covariates. A positive correlation was found between plasma LRG1 level and urinary albumin excretion (ρ = 0.256, <italic>p &lt;</italic>0.001). According to a multivariate model, the association between LRG1 and urinary albumin excretion remained significant, under adjustment for confounding factors (β = 0.285, <italic>p &lt;</italic>0.001).</p></sec><sec><title>Conclusion</title><p>Plasma LRG1 level was independently associated with urinary albumin excretion in patients with type 2 diabetes. This study suggests that LRG1 may be associated with increased excretion of urinary albumin in the early stages of diabetic nephropathy.</p></sec>