AUTHOR=Shaikh M. Guftar , Lucas-Herald Angela K. , Dastamani Antonia , Salomon Estebanez Maria , Senniappan Senthil , Abid Noina , Ahmad Sumera , Alexander Sophie , Avatapalle Bindu , Awan Neelam , Blair Hester , Boyle Roisin , Chesover Alexander , Cochrane Barbara , Craigie Ross , Cunjamalay Annaruby , Dearman Sarah , De Coppi Paolo , Erlandson-Parry Karen , Flanagan Sarah E. , Gilbert Clare , Gilligan Niamh , Hall Caroline , Houghton Jayne , Kapoor Ritika , McDevitt Helen , Mohamed Zainab , Morgan Kate , Nicholson Jacqueline , Nikiforovski Ana , O'Shea Elaine , Shah Pratik , Wilson Kirsty , Worth Chris , Worthington Sarah , Banerjee Indraneel TITLE=Standardised practices in the networked management of congenital hyperinsulinism: a UK national collaborative consensus JOURNAL=Frontiers in Endocrinology VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1231043 DOI=10.3389/fendo.2023.1231043 ISSN=1664-2392 ABSTRACT=

Congenital hyperinsulinism (CHI) is a condition characterised by severe and recurrent hypoglycaemia in infants and young children caused by inappropriate insulin over-secretion. CHI is of heterogeneous aetiology with a significant genetic component and is often unresponsive to standard medical therapy options. The treatment of CHI can be multifaceted and complex, requiring multidisciplinary input. It is important to manage hypoglycaemia in CHI promptly as the risk of long-term neurodisability arising from neuroglycopaenia is high. The UK CHI consensus on the practice and management of CHI was developed to optimise and harmonise clinical management of patients in centres specialising in CHI as well as in non-specialist centres engaged in collaborative, networked models of care. Using current best practice and a consensus approach, it provides guidance and practical advice in the domains of diagnosis, clinical assessment and treatment to mitigate hypoglycaemia risk and improve long term outcomes for health and well-being.