AUTHOR=Yang Meng , Wang Jing-Hua , Shin Joo-Hyun , Lee Dokyung , Lee Sang-Nam , Seo Jae-Gu , Shin Ji-Hee , Nam Young-Do , Kim Hojun , Sun Xiaomin 

TITLE=Pharmaceutical efficacy of novel human-origin Faecalibacterium prausnitzii strains on high-fat-diet-induced obesity and associated metabolic disorders in mice

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1220044

DOI=10.3389/fendo.2023.1220044

ISSN=1664-2392

ABSTRACT=<sec><title>Introduction</title><p>Obesity and related metabolic issues are a growing global health concern. Recently, the discovery of new probiotics with anti-obesity properties has gained interest.</p></sec><sec><title>Methods</title><p>In this study, four <italic>Faecalibacte-rium prausnitzii</italic> strains were isolated from healthy human feces and evaluated on a high-fat diet-induced mouse model for 12 weeks.</p></sec><sec><title>Results</title><p>The <italic>F. prausnitzii</italic> strains reduced body weight gain, liver and fat weights, and calorie intake while improving lipid and glucose metabolism in the liver and adipose tissue, as evidenced by regulating lipid metabolism-associated gene expression, including ACC1, FAS, SREBP1c, leptin, and adiponectin. Moreover, the <italic>F. prausnitzii</italic> strains inhibited low-grade inflammation, restored gut integrity, and ameliorated hepatic function and insulin resistance. Interestingly, the <italic>F. prausnitzii</italic> strains modulated gut and neural hormone secretion and reduced appetite by affecting the gut-brain axis. Supplementation with <italic>F. prausnitzii</italic> strains noticeably changed the gut microbiota composition.</p></sec><sec><title>Discussion</title><p>In summary, the novel isolated <italic>F. prausnitzii</italic> strains have therapeutic effects on obesity and associated metabolic disorders through modulation of the gut-brain axis. Additionally, the effectiveness of different strains might not be achieved through identical mechanisms. Therefore, the present findings provide a reliable clue for developing novel therapeutic probiotics against obesity and associated metabolic disorders.</p></sec>