AUTHOR=Wang Wencai , Ma Luyao , Zhao Yongqiang , Liu Menghao , Ye Wei , Li Xianfeng 

TITLE=Research progress on the role of the Wnt signaling pathway in pituitary adenoma

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1216817

DOI=10.3389/fendo.2023.1216817

ISSN=1664-2392

ABSTRACT=<p>Pituitary adenoma (PA) is the third most common central nervous system tumor originating from the anterior pituitary, but its pathogenesis remains unclear. The Wnt signaling pathway is a conserved pathway involved in cell proliferation, Self-renewal of stem cells, and cell differentiation. It is related to the occurrence of various tumors, including PA. This article reviews the latest developments in Wnt pathway inhibitors and pathway-targeted drugs. It discusses the possibility of combining Wnt pathway inhibitors with immunotherapy to provide a theoretical basis for the combined treatment of PA.</p>