AUTHOR=Liu Ying , Shuai Ping , Chen Wanjing , Liu Yuping , Li Dongyu 

TITLE=Association between Helicobacter pylori infection and metabolic syndrome and its components

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1188487

DOI=10.3389/fendo.2023.1188487

ISSN=1664-2392

ABSTRACT=<sec><title>Background and aim</title><p>The association between <italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) infection and metabolic syndrome (MetS) has been studied previously; however, the results remain controversial, which could be partly due to the different criteria used for defining MetS. We adopted five MetS criteria to provide better understanding of the association between <italic>H. pylori</italic> infection and MetS.</p></sec><sec><title>Methods</title><p>Physical examination data of 100,708 subjects were obtained from January 2014 to December 2018. MetS was defined based on five criteria including: International Diabetes Federation (IDF), The Third Report of the National Cholesterol Education Program Expert Panel, Adult Treatment Panel III (ATP III), Joint Statement of International Multi-Societies (JIS), Chinese Diabetes Society (CDS), and the Guidelines for the Prevention and Treatment of Type 2 Diabetes in China (2017 edition)(CDS DM). Multivariate logistic regression analysis was performed to elucidate the association between <italic>H. pylori</italic> infection and MetS and its components.</p></sec><sec><title>Results</title><p>The prevalence of MetS defined assessed using IDF, ATP III, JIS, CDS and CDS DM criteria was 15.8%, 19.9%, 23.7%, 8.7% and 15.4%, respectively. In males, the prevalence of MetS assessed using the five criteria in <italic>H. pylori</italic>-positive group was higher than that in negative-group; however, in females, same results were obtained using the three international criteria. In males, the prevalence of all MetS components was found to be higher in the <italic>H. pylori</italic>-positive group than those in the negative group; however, in females, only the prevalence of dyslipidemia and waist circumferences exhibited significant differences. Multivariate logistic regression analysis revealed that <italic>H. pylori</italic> infection in males was positively correlated with MetS. Additionally, <italic>H. pylori</italic> infection was found to be positively correlated with the waist circumference in the general population, and with hypertension and hyperglycemia in males.</p></sec><sec><title>Conclusions</title><p><italic>H. pylori</italic> infection was found to be positively associated with MetS in males in China.</p></sec>