AUTHOR=Chen Zi-yi , Liu Lei , Zhuang Xu-xiu , Zhang Yi-cong , Ma Ya-nan , Liu Yang , Wen De-liang 

TITLE=Lipid accumulation product is a better predictor of metabolic syndrome in Chinese adolescents: a cross-sectional study

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1179990

DOI=10.3389/fendo.2023.1179990

ISSN=1664-2392

ABSTRACT=<sec><title>Aim</title><p>Confirm and compare the degree of associations of non-traditional lipid profiles and metabolic syndrome (MetS) in Chinese adolescents, determine the lipid parameter with better predictive potential, and investigate their discriminatory power on MetS.</p></sec><sec><title>Methods</title><p>Medical measurements, including anthropometric measurements and biochemical blood tests, were undergone among a total sample of 1112 adolescents (564 boys and 548 girls) aged from 13 to 18 years. Univariate and multivariate logistic regression analyses were applied for assessing the relationships between the levels of traditional/non-traditional lipid profiles and MetS. We performed Receiver Operating Characteristic (ROC) analyses to mensurate the effectiveness of lipid accumulation product (LAP) on the diagnosis of MetS. Meanwhile, areas under the ROC curve and the cut-off values were calculated for MetS and its components.</p></sec><sec><title>Results</title><p>Univariate analysis showed that all our lipid profiles were closely associated with MetS (P&lt; 0.05). LAP index showed the closest association with MetS than the other lipid profiles. Additionally, ROC analyses indicated that the LAP index showed sufficient capabilities to identify adolescents with MetS and its components.</p></sec><sec><title>Conclusion</title><p>The LAP index is a simple and efficient tool to identify individuals with MetS in Chinese adolescents.</p></sec>