AUTHOR=Liu Zhoujun , Zhao Yueting , Han Xue , Hu Xin , Zhang Yuzhi , Xu Lan , Chen Guofang , Liu Chao , Xu Shuhang 

TITLE=Ultrasound-guided microwave ablation in the treatment of recurrent primary hyperparathyroidism in a patient with MEN1: a case report

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1175377

DOI=10.3389/fendo.2023.1175377

ISSN=1664-2392

ABSTRACT=<sec><title>Background</title><p>Multiple endocrine neoplasia type 1 (MEN1) is an inherited endocrine syndrome caused by the mutation in the tumor suppressor gene <italic>MEN1</italic>. The recurrence rate of primary hyperparathyroidism (PHPT) in patients with MEN1 after parathyroidectomy remains high, and the management of recurrent hyperparathyroidism is still challenging.</p></sec><sec><title>Case presentation</title><p>We reported a 44-year-old woman with MEN1 combined with PHPT who was diagnosed through genetic screening of the patient and her family members. After parathyroidectomy to remove one parathyroid gland, the patient suffered from persistent high levels of serum calcium and parathyroid hormone, which returned to normal at up to 8 months after ultrasound-guided microwave ablation (MWA) for bilateral parathyroid glands, suggesting an acceptable short-term prognosis.</p></sec><sec><title>Conclusion</title><p>Ultrasound-guided MWA for parathyroid nodules may be an effective therapeutic strategy for recurrent PHPT in MEN1 patients.</p></sec>