AUTHOR=Yang Zhikun , Di Yu , Ye Junjie , Yu Weihong , Guo Zijian 

TITLE=Comparison of the adjuvant effect of conbercept intravitreal injection at different times before vitrectomy for proliferative diabetic retinopathy

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1171628

DOI=10.3389/fendo.2023.1171628

ISSN=1664-2392

ABSTRACT=<sec><title>Purpose</title><p>To assess the optimal time of intravitreal conbercept (IVC) treatment prior to pars plana vitrectomy (PPV) in patients with severe proliferative diabetic retinopathy (PDR).</p></sec><sec><title>Method</title><p>This study was exploratory in nature. Forty-eight consecutive patients (48 eyes) with PDR were divided into four groups according to different IVC times (0.5 mg/0.05 mL) before PPV: group A (3 days), group B (7 days), group C (14 days), and group D (non-IVC). Intraoperative and postoperative effectiveness were assessed, and vitreous VEGF concentrations were detected.</p></sec><sec><title>Result</title><p>For intraoperative effectiveness, groups A and D had a higher incidence of intraoperative bleeding than groups B and C (<italic>P</italic> = 0.041). Furthermore, groups A-C required less surgical time than group D (<italic>P</italic> &lt; 0.05). For postoperative effectiveness, group B had a significantly higher proportion of visual acuity that improved or remained unchanged than group D (<italic>P</italic> = 0.014), and groups A-C had lower proportions of postoperative bleeding than group D. The vitreous VEGF concentration of group B (67.04 ± 47.24 pg/mL) was significantly lower than that of group D (178.29 ± 110.50 pg/mL) (<italic>P</italic> = 0.005).</p></sec><sec><title>Conclusion</title><p>IVC treatment that was administered 7 days preoperatively was associated with better effectiveness and a lower vitreous VEGF concentration than its administration at other time points.</p></sec>