AUTHOR=Roh Yu Jeong , Lee Su Jin , Kim Ji Eun , Jin You Jeong , Seol Ayun , Song Hee Jin , Park Jumin , Park So Hae , Douangdeuane Bounleuane , Souliya Onevilay , Choi Sun Il , Hwang Dae Youn 

TITLE=Dipterocarpus tuberculatus as a promising anti-obesity treatment in Lep knockout mice

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1167285

DOI=10.3389/fendo.2023.1167285

ISSN=1664-2392

ABSTRACT=<sec><title>Introduction</title><p>The therapeutic effects and mechanisms of <italic>Dipterocarpus tuberculatus</italic> (<italic>D. tuberculatus</italic>) extracts have been examined concerning inflammation, photoaging, and gastritis; however, their effect on obesity is still being investigated.</p></sec><sec><title>Methods</title><p>We administered a methanol extract of <italic>D. tuberculatus</italic> (MED) orally to <italic>Lep</italic> knockout (KO) mice for 4 weeks to investigate the therapeutic effects on obesity, weight gain, fat accumulation, lipid metabolism, inflammatory response, and β-oxidation.</p></sec><sec><title>Results</title><p>In <italic>Lep</italic> KO mice, MED significantly reduced weight gains, food intake, and total cholesterol and glyceride levels. Similar reductions in fat weights and adipocyte sizes were also observed. Furthermore, MED treatment reduced liver weight, lipid droplet numbers, the expressions of adipogenesis and lipogenesis-related genes, and the expressions of lipolysis regulators in liver tissues. Moreover, the iNOS-mediated COX-2 induction pathway, the inflammasome pathway, and inflammatory cytokine levels were reduced, but β-oxidation was increased, in the livers of MED-treated <italic>Lep</italic> KO mice.</p></sec><sec><title>Conclusion</title><p>The results of this study suggest that MED ameliorates obesity and has considerable potential as an anti-obesity treatment.</p></sec>