AUTHOR=Campopiano Maria Cristina , Ghirri Arianna , Prete Alessandro , Lorusso Loredana , Puleo Luciana , Cappagli Virginia , Agate Laura , Bottici Valeria , Brogioni Sandra , Gambale Carla , Minaldi Elisa , Matrone Antonio , Elisei Rossella , Molinaro Eleonora 

TITLE=Active surveillance in differentiated thyroid cancer: a strategy applicable to all treatment categories response

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1133958

DOI=10.3389/fendo.2023.1133958

ISSN=1664-2392

ABSTRACT=<p>Currently, the differentiated thyroid cancer (DTC) management is shifted toward a tailored approach based on the estimated risks of recurrence and disease-specific mortality. While the current recommendations on the management of metastatic and progressive DTC are clear and unambiguous, the management of slowly progressive or indeterminate disease varies according to different centers and different physicians. In this context, active surveillance (AS) becomes the main tool for clinicians, allowing them to plan a personalized therapeutic strategy, based on the risk of an unfavorable prognosis, and to avoid unnecessary treatment. This review analyzes the main possible scenarios in treated DTC patients who could take advantage of AS.</p>