AUTHOR=Luo Hui , Jiao Qibin , Shen Chuanbin , Shao Chenyi , Xie Jinyan , Chen Yue , Feng Xinglin , Zhang Xingwei 

TITLE=Unraveling the roles of endoplasmic reticulum-associated degradation in metabolic disorders

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1123769

DOI=10.3389/fendo.2023.1123769

ISSN=1664-2392

ABSTRACT=<p>Misfolded proteins retained in the endoplasmic reticulum cause many human diseases. ER-associated degradation (ERAD) is one of the protein quality and quantity control system located at ER, which is responsible for translocating the misfolded proteins or properly folded but excess proteins out of the ER for proteasomal degradation. Recent studies have revealed that mice with ERAD deficiency in specific cell types exhibit impaired metabolism homeostasis and metabolic diseases. Here, we highlight the ERAD physiological functions in metabolic disorders in a substrate-dependent and cell type-specific manner.</p>