AUTHOR=Yu Longshan , Chen Yan , Xu Ming , Li Rongfu , Zhang Juan , Zhu Shouwei , He Zongbao , Chen Mingwei , Wang Gaosheng 

TITLE=Association of weight-adjusted-waist index with asthma prevalence and the age of first asthma onset in United States adults

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1116621

DOI=10.3389/fendo.2023.1116621

ISSN=1664-2392

ABSTRACT=<sec><title>Objective</title><p>The objective of this study was to assess whether the weight-adjusted-waist index(WWI) is associated with the prevalence of asthma and age when first asthma onset appears in US adults.</p></sec><sec><title>Methods</title><p>For analysis we selected participants from the National Health and Nutrition Examination Survey(NHANES)database between 2001 and 2018. A dose-response curve was calculated using logistic regression,subgroup analysis,and a dose-response curve.</p></sec><sec><title>Results</title><p>The study included 44480 people over the age of 20,including 6061 reported with asthma, and the increase in asthma prevalence was 15% associated with each unit increase in the WWI, after adjusting for all confounders(odds ratio(OR)=1.15,95% CI:1.11,1.20). The sensitivity analysis was performed by trichotomizing the WWI, and compared to the lowest tertile, the highest tertile WWI group displayed a 29% increase in asthma prevalence(OR=1.29,95% CI:1.19,1.40). A nonlinear correlation was found between the WWI index and the risk of asthma onset, with a threshold saturation effect indicating an inflection point of 10.53 (log-likelihood ratio test, P&lt;0.05), as well as a positive linear correlation with age at first asthma onset.</p></sec><sec><title>Conclusions</title><p>A higher WWI index was associated with an increased prevalence of asthma and an older age of first asthma onset.</p></sec>