AUTHOR=Liu Xindong , Chen Ying , Liu Tao , Cai Ling , Yang Xiaofeng , Mou Chuan 

TITLE=The effects of Sodium-glucose cotransporter 2 inhibitors on adipose tissue in patients with type 2 diabetes: A meta-analysis of randomized controlled trials

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1115321

DOI=10.3389/fendo.2023.1115321

ISSN=1664-2392

ABSTRACT=<sec><title>Purpose</title><p>To systematically evaluate the effect of Sodium-glucose cotransporter 2 (SGLT2) inhibitors on adipose tissue in patients with type 2 diabetes.</p></sec><sec><title>Methods</title><p>We searched PubMed, Cochrane Library, EMBASE, and Web of science databases for literature pertaining to Randomized controlled trials (RCTs) of SGLT2 inhibitors in treating type 2 diabetes patients. The retrieval time was from the date of establishment of the databases to September 1, 2022. Meta-analysis was performed using RevMan5.4 software.</p></sec><sec><title>Results</title><p>Totally 551 patients were included in 10 articles. Meta-analysis results showed that compared with the control group, the visceral adipose tissue (WMD = -16.29 cm<sup>2</sup>, 95% CI: -25.07 ~ -7.50, P&lt;0.00001), subcutaneous adipose tissue (WMD = -19.34 cm<sup>2</sup>, 95% CI: -36.27 ~ -2.41, P&lt;0.00001), body weight (WMD = -2.36 kg, 95% CI: -2.89 ~ -1.83, P&lt;0.00001) and triglyceride (WMD = -24.41 mg/dl, 95% CI: -45.79 ~ -3.03, P = 0.03) of the trial group significantly reduced.</p></sec><sec><title>Conclusion</title><p>SGLT2 inhibitors cause significant reductions in visceral adipose tissue, subcutaneous adipose tissue, body weight and triglycerides in type 2 diabetes patients, which may be attributed to the protective effect of the inhibitors on cardiovascular system.</p></sec>