AUTHOR=Yan Qun , Hu Weiting , Tian Yan , Li Xu , Yu Yuan , Li Xing , Feng Bo 

TITLE=Probiotics intervention in preventing conversion of impaired glucose tolerance to diabetes: The PPDP follow-on study

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1113611

DOI=10.3389/fendo.2023.1113611

ISSN=1664-2392

ABSTRACT=<sec><title>Objectives</title><p>The purpose of this study was to assess the incidence of type 2 diabetes mellitus (T2DM) after 6 years in patients with IGT who received early probiotic intervention in the Probiotics Prevention Diabetes Program (PPDP) trial.</p></sec><sec><title>Methods</title><p>77 patients with IGT in the PPDP trial were randomized to either probiotic or placebo. After the completion of the trial, 39 non-T2DM patients were invited to follow up glucose metabolism after the next 4 years. The incidence of T2DM in each group was assessed using Kaplan-Meier analysis. The 16S rDNA sequencing technology was used to analyze gut microbiota’s structural composition and abundance changes between the groups.</p></sec><sec><title>Results</title><p>The cumulative incidence of T2DM was 59.1% with probiotic treatment versus 54.5% with placebo within 6 years, there was no significant difference in the risk of developing T2DM between the two groups (<italic>P</italic>=0.674).</p></sec><sec><title>Conclusions</title><p>Supplemental probiotic therapy does not reduce the risk of IGT conversion to T2DM.</p></sec><sec><title>Clinical Trial Registration</title><p><uri xlink:href="https://www.chictr.org.cn/showproj.aspx?proj=5543" xmlns:xlink="http://www.w3.org/1999/xlink">https://www.chictr.org.cn/showproj.aspx?proj=5543</uri>, identifier ChiCTR-TRC-13004024.</p></sec>