AUTHOR=Xiong Yan , He Tongxiang , Liu Weiyin Vivian , Zhang Yao , Hu Shuang , Wen Donglin , Wang Yanan , Zhang Peisen , He Fan , Li Xiaoming 

TITLE=Quantitative assessment of lumbar spine bone marrow in patients with different severity of CKD by IDEAL-IQ magnetic resonance sequence

JOURNAL=Frontiers in Endocrinology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.980576

DOI=10.3389/fendo.2022.980576

ISSN=1664-2392

ABSTRACT=<sec><title>Background</title><p>Chronic kidney disease (CKD) has a significant negative impact on bone health. Bone marrow is an essential component of bone, mainly composed of trabecular bone and fat. The IDEAL-IQ sequence of MRI allows indirect quantification of trabecular bone mass by R2* and direct quantification of bone marrow fat content by FF map, respectively.</p></sec><sec><title>Objective</title><p>Our objective was to explore the association of CKD severity with bone marrow using IDEAL-IQ and whether mineral and bone metabolism markers alter this association.</p></sec><sec><title>Method</title><p>We recruited 68 CKD patients in this cross-sectional research (15 with CKD stages 3-4, 26 with stage 5, and 27 with stage 5d). All patients underwent lumbar spine IDEAL-IQ, BMD, and several bone metabolism markers (iPTH, 25-(OH)-VitD, calcium and phosphorus). Multiple linear regression analysis was used to examine the association of CKD severity with MRI measurements (R2* and FF).</p></sec><sec><title>Results</title><p>More severe CKD was associated with a higher R2* value [CKD 5d versus 3-4: 30.077 s<sup>-1</sup> (95% CI: 12.937, 47.217), <italic>P</italic> for trend &lt; 0.001], and this association was attenuated when iPTH was introduced [CKD 5d versus 3-4: 19.660 s<sup>-1</sup> (95% CI: 0.205, 39.114), <italic>P</italic> for trend = 0.042]. Furthermore, iPTH had an association with R2* value [iPTH (pg/mL): 0.033 s<sup>-1</sup> (95% CI: 0.001, 0.064), <italic>P</italic> = 0.041]. Besides, FF was mainly affected by age and BMI, but not CKD.</p></sec><sec><title>Conclusions</title><p>The bone marrow R2* value measured by IDEAL-IQ sequence is associated with CKD severity and iPTH. The R2* of IDEAL-IQ has the potential to reflect lumbar bone changes in patients with CKD.</p></sec>