AUTHOR=Kano Mayuko , Mizutani Eiji , Homma Shota , Masaki Hideki , Nakauchi Hiromitsu 

TITLE=Xenotransplantation and interspecies organogenesis: current status and issues

JOURNAL=Frontiers in Endocrinology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.963282

DOI=10.3389/fendo.2022.963282

ISSN=1664-2392

ABSTRACT=<p>Pancreas (and islet) transplantation is the only curative treatment for type 1 diabetes patients whose β-cell functions have been abolished. However, the lack of donor organs has been the major hurdle to save a large number of patients. Therefore, transplantation of animal organs is expected to be an alternative method to solve the serious shortage of donor organs. More recently, a method to generate organs from pluripotent stem cells inside the body of other species has been developed. This interspecies organ generation using blastocyst complementation (BC) is expected to be the next-generation regenerative medicine. Here, we describe the recent advances and future prospects for these two approaches.</p>