AUTHOR=Zhang Mingyu , Yin Taoyuan , Xia Feng , Xia Suhong , Zhou Wangdong , Zhang Yu , Han Xu , Zhao Kai , Feng Lina , Dong Ruonan , Tian Dean , Yu Yan , Liao Jiazhi TITLE=Hypertriglyceridemia may contribute to stroke and pancreatitis: A case report and review of the literature JOURNAL=Frontiers in Endocrinology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.960343 DOI=10.3389/fendo.2022.960343 ISSN=1664-2392 ABSTRACT=

Hypertriglyceridemia (HTG) is one of the most common clinical dyslipidemia. Nevertheless, stroke and acute pancreatitis co-occurrence due to hypertriglyceridemia are extremely rare. We present a case of hypertriglyceridemia-associated stroke and pancreatitis in a 39-year-old woman. The patient’s laboratory tests reported high triglyceride concentrations beyond the instrument’s detection range, and radiological examination showed typical signs of cerebral infarction and acute pancreatitis. The patient received combined blood purification therapy, intravenous thrombolysis with urokinase, and conservative treatment of pancreatitis. We discuss the clinical features, pathogenesis, diagnosis, and treatment of hypertriglyceridemic stroke and pancreatitis combined with the relevant literature. We reviewed the mechanisms by which triglycerides contribute to atherosclerosis and acute pancreatitis. We point out the superiority of combined blood purification therapy and caution physicians about the effects of prescribed drugs on blood lipids.