AUTHOR=Braun Jessica L. , Ryoo Jisook , Goodwin Kyle , Copeland Emily N. , Geromella Mia S. , Baranowski Ryan W. , MacPherson Rebecca E. K. , Fajardo Val A. TITLE=The effects of neurogranin knockdown on SERCA pump efficiency in soleus muscles of female mice fed a high fat diet JOURNAL=Frontiers in Endocrinology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.957182 DOI=10.3389/fendo.2022.957182 ISSN=1664-2392 ABSTRACT=
The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) pump is responsible for the transport of Ca2+ from the cytosol into the sarcoplasmic reticulum at the expense of ATP, making it a regulator of both muscle relaxation and muscle-based energy expenditure. Neurogranin (Ng) is a small protein that negatively regulates calcineurin signaling. Calcineurin is Ca2+/calmodulin dependent phosphatase that promotes the oxidative fibre type in skeletal muscle and regulates muscle-based energy expenditure. A recent study has shown that calcineurin activation reduces SERCA Ca2+ transport efficiency, ultimately raising energy expenditure. Since the biomedical view of obesity states that it arises as an imbalance between energy intake and expenditure which favors the former, we questioned whether heterozygous Ng deletion (