AUTHOR=Zhu Cuilin , Liu Qing , Li Xin , Wei Ran , Ge Tongtong , Zheng Xiufen , Li Bingjin , Liu Kexiang , Cui Ranji 

TITLE=Hydrogen sulfide: A new therapeutic target in vascular diseases

JOURNAL=Frontiers in Endocrinology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.934231

DOI=10.3389/fendo.2022.934231

ISSN=1664-2392

ABSTRACT=<p>Hydrogen sulfide (H<sub>2</sub>S) is one of most important gas transmitters. H<sub>2</sub>S modulates many physiological and pathological processes such as inflammation, oxidative stress and cell apoptosis that play a critical role in vascular function. Recently, solid evidence show that H<sub>2</sub>S is closely associated to various vascular diseases. However, specific function of H<sub>2</sub>S remains unclear. Therefore, in this review we systemically summarized the role of H<sub>2</sub>S in vascular diseases, including hypertension, atherosclerosis, inflammation and angiogenesis. In addition, this review also outlined a novel therapeutic perspective comprising crosstalk between H<sub>2</sub>S and smooth muscle cell function. Therefore, this review may provide new insight inH<sub>2</sub>S application clinically.</p>