AUTHOR=Bray David P. , Mannam Sai , Rindler Rima S. , Quillin Joseph W. , Oyesiku Nelson M. 

TITLE=Surgery for acromegaly: Indications and goals

JOURNAL=Frontiers in Endocrinology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.924589

DOI=10.3389/fendo.2022.924589

ISSN=1664-2392

ABSTRACT=<p>Acromegaly is a disease that occurs secondary to high levels of GH, most often from a hormone-secreting pituitary adenoma, with multisystem adverse effects. Diagnosis includes serum GH and IGF-1 levels, and obtaining an MRI pituitary protocol to assess for a functional pituitary adenoma. Attempted gross total resection of the GH-secreting adenoma is the gold standard in treatment for patients with acromegaly for a goal of biochemical remission. Medical and radiation therapies are available when patients do not achieve biochemical cure after surgical therapy.</p>