AUTHOR=Guan Chun-Yi , Cao Jing-Li , Zhang Lu , Wang Xue-Qin , Ma Xu , Xia Hong-Fei 

TITLE=miR-199a Is Upregulated in GDM Targeting the MeCP2-Trpc3 Pathway

JOURNAL=Frontiers in Endocrinology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.917386

DOI=10.3389/fendo.2022.917386

ISSN=1664-2392

ABSTRACT=<p>Gestational diabetes mellitus (GDM), the most common medical pregnancy complication, has become a growing problem. More and more studies have shown that microRNAs are closely related to metabolic processes. The purpose of this paper is to investigate the role of up-regulation of miR-199a-5p expression in GDM. We found that miR-199a-5p was significantly up-regulated in the placenta of GDM patients compared with normal pregnant women, and expressed in placental villi. miR-199a-5p can regulate the glucose pathway by inhibiting the expression of methyl CpG-binding protein 2 (MeCP2) and down-regulating canonical transient receptor potential 3 (Trpc3). This suggests that miR-199a-5p may regulate the glucose pathway by regulating methylation levels, leading to the occurrence of GDM.</p>